Received single high dose of psilocybin-containing mushrooms
By Jim Hoft, The Gateway Pundit
A stunning medical case is raising new questions about what may still be possible for patients suffering from advanced Alzheimer’s disease.
A Japanese-American woman in her 80s who had spent five years barely speaking, unable to walk on her own, and incontinent of urine started talking about her own life again roughly 19 hours after a single oral dose of psilocybin-containing mushrooms, according to a case report published May 28, 2026, in Frontiers in Neuroscience.
The paper, “Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration,” was written by Marcos Lago, Mariana Cerveira, and Joe Xavier Simonet of the Associação Cruz de Ankh in São Paulo, Brazil. It is one patient. It is not a randomized trial. The authors are explicit that the findings “do not imply disease reversal.”
The patient had a clinically diagnosed 10-year history of Alzheimer’s disease, including five years of marked hypofunction.
At baseline she spoke mostly in single syllables. She had chronic urinary incontinence, needed help to walk, could not dress herself, had a flat affect, trouble swallowing, and severe loss of spontaneous communication.
She lived under continuous family and caregiver supervision. Formal biomarker confirmation and advanced imaging were not available, and the authors note that a vascular or mixed contribution cannot be fully excluded.